The investigators found that reproductive risk factors varied considerably by breast cancer subtype. Their analysis included 1,023 women with breast cancer whose cells express the estrogen and progesterone receptors (called luminal cancers), 39 women with HER2-overexpressing breast cancer, and 78 triple-negative cases (no expression of estrogen, progesterone, or HER2 receptors). The study also included 1,476 women without breast cancer. ? They added that additional studies on the causes of breast cancer subtypes are needed to better understand the biology of the disease. Learn more about our commitment to providing complete, accurate, and private breast cancer information. The study?s results suggest that there are distinct and separate hormonal risk factors associated with different subtypes of breast cancer. Women with what is referred to as "triple-negative" breast cancer are more likely than other women with breast cancer to experience a relapse, a new study by Canadian researchers shows. Despite having a high risk of early recurrence, the study indicates that triple-negative breast cancer patients who remain disease-free for eight years are unlikely to die of breast cancer and may be "cured" of their disease.
Breast Feeding Will Lowers Risk Of Breast Cancer
Breastfeeding for 6 months or longer was associated with a lower risk of luminal cancer as well as triple-negative cancer, a type that can be particularly aggressive and difficult to treat. Understanding the specific type of breast cancer can help you ask better questions and work with your physicians to get the best breast cancer treatments. For more information on the types and stages of breast cancer, watch Beyond the Shock®. Medullary carcinoma accounts for 15% of all breast cancer types. Infiltrating lobular carcinoma is a type of breast cancer that usually appears as a subtle thickening in the upper-outer quadrant of the breast. Making up about 2% of all breast cancer diagnosis, tubular carcinoma cells have a distinctive tubular structure when viewed under a microscope. Typically this type of breast cancer is found in women aged 50 and above. Inflammatory breast cancer is a rare and very aggressive type of breast cancer that causes the lymph vessels in the skin of the breast to become blocked.
Breast Cancer Risk
The study's results suggest that there are distinct and separate hormonal risk factors associated with different subtypes of breast cancer. Amanda Phipps, a predoctoral research associate at the Fred Hutchinson Cancer Research Center in Seattle, and her colleagues conducted a study to better understand the specific risk factors for the subtypes of breast cancer, which are classified by expression of the estrogen receptor, the progesterone receptor, and the HER2 receptor. The investigators found that reproductive risk factors varied considerably by breast cancer subtype. Breastfeeding for 6 months or longer was associated with a lower risk of luminal cancer as well as triple-negative cancer, a type that can be particularly aggressive and difficult to treat. Both late age at menopause and use of estrogen plus progestin hormone therapy were associated with an increased risk of luminal disease. Finally, no differences in risks associated with number of children or the age when a woman first gave birth were observed by subtype. The study authors concluded that their results indicate that "certain reproductive factors may have a greater impact on risk of certain molecular subtypes of disease compared to others. Despite having a high risk of early recurrence, the study indicates that triple-negative breast cancer patients who remain disease-free for eight years are unlikely to die of breast cancer and may be "cured" of their disease. Insulin resistance, hyperinsulinemia, and changes in the signaling of growth hormones and steroid hormones associated with diabetes may affect the risk of breast cancer. Despite many proposed potential pathways, the mechanisms underlying an association between diabetes and breast cancer risk remain unclear, particularly because the 2 diseases share several risk factors, including obesity, a sedentary lifestyle, and possibly intake of saturated fat and refined carbohydrates, that may confound this association. Although the metabolic syndrome is closely related to diabetes and embraces additional components that might influence breast cancer risk, the role of the metabolic syndrome in breast carcinogenesis has not been studied and thus remains unknown.
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